Clinical Features of IgE mediated cow's milk protein allergy
Possible dermatological features include:
- pruritus
- erythema
- acute urticaria (localised or generalised)
- acute angioedema (most commonly in the lips and face, and around the eyes
Possible gastroenterological features include:
- agioedema of the lips, tongue, and palate
- oral pruritus
- colicky abdominal pain
- nausea
- vomiting
- diarrhoea
Respiratory system (usually in combination with one or more of the above symptoms and signs)
- upper respiratory tract symptoms (nasal itching, sneezing, rhinorrhoea, or congestion, with or without conjunctivitis)
- lower respiratory tract symptoms (cough, chest tightness, wheezing, or shortness of breath)
Other
- signs or symptoms of anaphylaxis or other systemic allergic reactions
Clinical Features of non-IgE mediated cow's milk protein allergy
Possible dermatological features include:
- pruritus
- erythema
- atopic eczema
Possible gastroenterological features include:
- gastro-oesophageal reflux disease
- loose or frequent stools
- bood and /or mucus in the stools
- abdominal pain
- infantile colic
- constipation
- perianal redness
- pallor and tiredness
- food refusal or aversion
- faltering growth plus one or more gastrointestinal symptoms above (with or without significant atopic eczema)
Reference:
- NICE. Food allergy in children and young people: diagnosis and assessment of food allergy in children and young people in primary care and community settings. CG 116. 2011
- Walsh J et al. Differentiating milk allergy (IgE and non-IgE mediated) from lactose intolerance: understanding the underlying mechanisms and presentations. Br J Gen Pract 2016; DOI: 10.3399/bjgp16X686521