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Treatment of colon cancer

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Treatment options of colonic carcinoma consists of

surgical resection of the lesion.
- colectomy with en bloc removal of the regional lymph nodes in resectable non metastatic colon cancer (1)
- resection of metastatic disease and colectomy (same time or separately) in metastatic tumours which are considered resectable (2)
chaemotherapy
- adjuvant chaemotherapy after surgery for high-risk stage II and stage III colon cancer (2)
- preoperative chaemotherapy for resectable metastatic disease (1)
- palliative chemotherapy in patients with locally advanced or metastatic disease has been shown to reduce death and progression at 12 months (1). The findings translate into a 16% absolute difference in survival and a 25% increase in progression free survival (increases in 3.7 months in median survival and 6 months in median progression free survival) in patients treated with palliative chemotherapy e.g. 5-fluorouracil alone or in combination with other chemotherapeutic agents.
biological agents (2,3)

The response to radiotherapy is limited by the difficulty of directing the radiation beam at the tumour without damaging surrounding structures, e.g. the bladder.

Reference:

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Treatment of colon cancer

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