Cisapride has a similar structure to metoclopramide. It is rapidly absorbed, peaking in plasma concentration within 2 hours and having a half life of 10 hours.
It is prone to significant first pass hepatic metabolism, less than half reaching the systemic circulation. Hence, hepatic damage can prolong the drug's half-life.
It is highly protein-bound, appearing minimally in breast milk and not traversing the blood-brain barrier.
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