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Management

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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The treatment of Gorlin's Syndrome should ideally be co-ordinated by a specialist as input may be required from many teams including dermatology, plastic surgery, dentists, cardiologists, oncologists and orthopaedic surgeons.

Basal cell carcinoma lesions can be treated with surgical excision when they arise if they are relatively few in number. Large and rapidly developing crops of lesions may require alternative modalities such as laser ablation, photodynamic therapy or 5-fluouracil cream. Retinoid therapy may have some utility as a prophylactic treatment for slowing the development of skin lesions.

Odontogenic keratocysts are removed but they have a high tendency to recur.

More rarely, associated medulloblastoma may be treated with resection, chemotherapy and radiation.

Gorlin's Syndrome patients should be counselled to avoid sun and radiographic exposure due to their suggested heightened sensitivity to potential mutagenesis.


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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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