Cholestyramine

Indications:

• moderate hypercholesterolaemia with normal HDL levels
• familial hypercholesterolaemia.

Dosage:

• 12-24g daily in single or divided doses

Side effects include:

• nausea
• constipation
• heartburn
• flatulence
• rashes

Contra-indications include:

• complete biliary obstruction
• pregnancy

Cautions:

• folic acid supplements may be required, particularly if maximal doses are used.
• avoid taking other medications with cholestyramine;at least 1 hour before and 4 hours after, should separate ingestion of cholestyramine from that of other drugs with other drugs taken ideally first. - malabsorption of other drugs may occur, particularly: - thyroid hormones - fat soluble vitamins - oral contraception failure may occur

Comments:

• Cholestyramine can be mixed with food, particularly muesli or fruit juice to enhance compliance. Avoid mixing with carbonated drinks.