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Slowly progressive disorder

Authoring team

Slowly progressive disorder (Primary Progressive MS - PPMS)

  • 2017 criteria:
    • required 1 year of continuous clinical progression plus meeting two out of three specific structural/laboratory criteria.
  • 2024 revision:
    • requirement for 1 year of documented clinical progression remains the mandatory starting point
      • the 2024 criteria simplify the biological confirmation
      • the optic nerve is now a fifth anatomical zone and the Kappa Free Light Chain (kFLC) index is an approved fluid biomarker, it is now structurally easier and highly accurate to biologically confirm PPMS once that 1 year of progression has been established

Reference:

  1. Montalban X et al. Diagnosis of multiple sclerosis: 2024 revisions of the McDonald criteria. Lancet Neurol. 2025 Oct;24(10):850-865. doi: 10.1016/S1474-4422(25)00270-4. Erratum in: Lancet Neurol. 2025 Nov;24(11):e13.

 

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