The aetiology of secretory otitis media is not fully understood.
The following factors have been implicated which is thought to increase the risk of developing OME:
- age - 6 years or younger
 - household smoking
 - attending a day care centre
 - large number of siblings
 - low socioeconomic group
 - recurrent upper respiratory tract infections
 - bottle feeding (1).
 
The importance of Eustachian tube dysfunction is, however, widely accepted. One possible mechanism is that negative pressure develops within the middle ear cavity as a result of Eustachian tube dysfunction and the continual absorption of oxygen by respiratory epithelium. This negative pressure then encourages the formation of a mucosal transudate. Some common causes of tubal dysfunction are
- functional problems and its intrinsic system of opening and closing
 - immunological and genetic disorders
 - gastroesophageal reflux
 - rhinosinusitis
 - enlarged adenoid (2)
 
Thus, secretory otitis media may be caused by:
- nasopharyngeal obstruction:
- large adenoids
 - nasopharyngeal tumours in adults
 
 - otic barotrauma
 - sinusitis
 - there is an increased incidence in
- cleft palate - due to impaired function of the Eustachian tube associated with palatal anomaly (2)
 - Down's syndrome - caused by impaired immune system and mucosal abnormality which results in an increased susceptibility to ear infection (2)
 
 - allergic rhinitis may also predispose to secretory otitis media by affecting Eustachian tube function.
 - passive smoking may be a factor
 
However, many cases of secretory otitis media have no apparent cause.
Reference:
- Williamson I. Otitis media with effusion. Clinical Evidence 2006
 - Di Francesco R et al. Craniofacial morphology and otitis media with effusion in children. Int J Pediatr Otorhinolaryngol. 2008;72(8):1151-8
 - NICE. Otitis media with effusion in under 12s. NICE guideline NG233. Published August 2023.