Anaemia (macrocytic with a megaloblastic bone marrow)
Common causes include:
- vitamin B12 deficiency
- folate deficiency
Rare causes include:
- inherited:
- orotic aciduria
- Lesch-Nyhan syndrome
- homocystinuria
- methylmalonic aciduria
- acquired:
- myelodysplasia
- metabolic inhibition by drugs:
- 6-mercaptopurine
- azathioprine
- ganciclovir
- aciclovir
- fluorouracil
- hydroxycarbamide (former British Approved Name, hydroxyurea)
- cytosine arabinoside
- cyclophosphamide
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