Methotrexate and fluconazole
Liver toxicity
- concomitant use of methotrexate and fluconazole can increase the risk of liver toxicity
Suggested management options (1)
- routine monitoring of methotrexate should detect any signs of liver toxicity
- In the presence of a severe acute or chronic infection, some people on stable methotrexate therapy can miss doses of methotrexate whilst taking the course of fluconazole
- restart methotrexate once they feel better.
Reference:
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