Switching antidepressant (vortioxetine to serotonin and noradrenaline reuptake inhibitors (SNRIs) (e.g. duloxetine or venlafaxine)) in adults
Vortioxetine to serotonin and noradrenaline reuptake inhibitors (SNRIs)
- is limited experience with this switch so extra caution is required to avoid serotonin syndrome
Direct switch
- a direct switch, i.e. stopping one antidepressant and then starting the new antidepressant the following day, is normally possible
Stop, washout and switch
- alternatively, stop vortioxetine; wait for a period before starting the SNRI. Clinicians should decide the duration of the washout period on a case-by-case basis
Reference:
- NHS Specialist Pharmacy Service (February 2023). Vortioxetine to other antidepressants: switching in adults
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