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Switching antidepressant - SNRI (e.g. duloxetine or venlafaxine) to moclobemide in adults

Authoring team

SNRIs to moclobemide

Taper, washout and switch

  • gradually reduce the dose of the SNRI and stop; wait 7 days before starting moclobemide

  • cross-tapering is not recommended due to the high risk of serotonin syndrome

Reference:

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