Prostaglandin E2
Prostaglandin E2 has effects including:
- oxytocic action, although weaker than prostaglandin F2 alpha
- bronchodilator
- along with PGE1, maintain ductus arteriosus patency in the newborn as a result of its general vasodilatory action
- promotes renal natriuresis and diuresis
- gastric inhibition of acid secretion and increase in mucous secretion
- positively inotropic on sinoatrial node
- increase motility and secretions in gastrointestinal tract
- hypothalamic pyretic
- endocrine actions:
- GH, ACTH, LH, TSH release from pituitary
- insulin release from pancreas
- steroid release from adrenal cortex
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