Immune deficiency and meningitis
Immunodeficiency and meningitis correlate as follows:
Cell mediated - T cells or macrophages lost:
- lymphoma - Hodgkins, transplants, steroids, AIDS
- get intracellular organisms - listeria
Humoral - antibodies absent:
- CLL, myeloma, Hodgkins treatment
- encapsulated organisms, S pneumonia, H. influenzae
Neutropenia/ neutrophil dysfunction:
- pseudomonas, with no meningeal inflammation
Asplenia:
- autosplenectomy, trauma, elecitve splenectomy, irradiation
- encapsulated organisms - S.aureus, H. influenzae, N.meningitidis
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