Tetrahydrofolate
Tetrahydrofolate is the main active metabolite of dietary folate. It is vital as a coenzyme in reactions involving transfers of single carbon groups.
Examples of pathways in which tetrahydrofolate has a role include:
- purine synthesis
- pyrimidine synthesis
- amino acid conversions:
- histidine to glutamic acid
- homocysteine to methionine
- serine to glycine
As nucleic and amino acid synthesis is affected by a deficiency of tetrahydrofolate, actively dividing and growing cells tend to be the first affected.
Related pages
Create an account to add page annotations
Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.