Paget's disease of bone
Paget's disease (Synonym: osteitis deformans) is the second most common metabolic bone disease after osteoporosis and is the commonest cause of bone dysplasia. (1)
- it is characterised by one or more areas of aggressive osteoclast-mediated bone resorption followed by imperfect osteoblast-mediated bone repair
Involvement of the disease is monostotic in 15% of cases and polyostotic in the remainder.
- can affect any bone but frequently the axial skeleton is involved. The usual sites include
- pelvis
- femur
- lumbar spine
- skull
- tibia
- when long bones are affected they may become bowed
- thickening of the skull may lead to compression of cranial nerves with consequent palsies.
Many cases of Paget's disease are asymptomatic.
Reference:
- Cook SJ, Wall C. Paget's disease of bone: A clinical update. Aust J Gen Pract. 2021 Jan-Feb;50(1-2):23-29.
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