Natural history
The progression of multiple sclerosis may follow one of four clinical patterns:
- benign form:
- characterised by abrupt onset, good remission and a long latent period before the next presentation
- this intermittent pattern is seen in about 55% of cases of MS
- relapsing with accumulating disability:
- is seen in about 25% of patients
- is seen in about 25% of patients
- slowly progressive form with no relapse or remission:
- is seen in about 5% of cases
- is more common in older age groups
- acute or primary progressive form:
- characterised by explosive onset, and possibly death within months
- it is seen in about 15% of cases
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