There is a history of antibiotic usage. This condition is most common after treatment with particular antibiotics - lincomycin and clindamycin; ampicillin and amoxycillin; cephalosporins.
In surgical patients, this condition most often occurs post-operatively.
The patient develops a worsening and eventually prostrating diarrhoea. This condition may be fatal, especially in the elderly.
The patient may develop toxic megacolon.
The condition is associated with a high recurrence rate.
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