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Haemoglobin C ( HbC ) disease

Authoring team

  • genetic defect of haemoglobin due to a substitution of lysine for glutamic acid in the ß-globin chain at position 6 (same point as substitution in HbS)
  • frequent in West Africa
  • HbC tends to form rhomboidal crystals
  • in homozygotes - mild haemolytic anaemia with marked target cell formation, microspherocytes and cells with rhomboidal shape; splenomegaly
  • in heterozygotes (carriers) - a few target cells only

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