This is a water soluble vitamin that is found in sources such as whole-grain products, eggs, pork, nuts, liver and yeast. It is often degraded by overcooking.
Absorption takes place within the jejunum by secondary active transport along with sodium ions. It is excreted renally. There is minimal body storage.
Thiamine's key role is as a coenzyme. As a pyrophosphate, it takes part in a number of reactions involved in carbohydrate metabolism.
Deficiency can result in a spectrum of clinical states ranging from beriberi to Korsakoff's psychosis.
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