NASH and fibrosis progression

Fibrosis Progression in NASH

Approximately 40% of NASH patients progress to fibrosis globally (1,2)

• 5% and 10% of patients with NASH diagnosed on their initial biopsy will present with clinically significant fibrosis at this initial biopsy, and an additional 15-20% will progress to advanced fibrosis in less than a decade (2)
  
• age and presence of inflammation on initial biopsy are independent predictors of progression to advanced fibrosis (3)

Reference:

1. Younossi Z, Koenig A, Abdelatif D, Fazel Y, Henry L,Wymer M. Global epidemiology of nonalcoholic fatty liver disease - meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology.2016;64(1):73-84
2. Argo C, Northup P, Al-Osaimi A, Caldwell S. Systematic review of risk factors for fibrosis progressionin non-alcoholic steatohepatitis. J Hepatol. 2009;51(2):371-9.
3. Hashimoto E, Tokushige K. Prevalence, gender,ethnic variations, and prognosis of NASH. J Gastroenterol. 2011;46(suppl 1):63–9.