This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Go to /pro/cpd-dashboard page

This page is worth 0.05 CPD credits. CPD dashboard

Go to /account/subscription-details page

This page is worth 0.05 CPD credits. Upgrade to Pro

IONA study (Impact Of Nicorandil in Angina)

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

  • the IONA study compared nicorandil (titrated to 20mg twice daily) with placebo in 5,126 high-risk patients with stable angina
  • all patients required further antianginal treatment at recruitment and took the study drug in addition to optimised standard antianginal therapy
  • IONA revealed that fewer patients in the nicorandil group experienced the combined primary end-point of coronary heart disease (CHD) death, non-fatal MI or unplanned admission to hospital with cardiac chest pain (13.1% vs.15.5%; relative risk 0.83, 95% CI 0.72-0.97; mean follow-up 1.6 years). The main benefit for the group treated with nicorandil was a reduction in unplanned admission, because there was no difference between nicorandil and placebo in the combined secondary endpoint of CHD death or nonfatal MI

Notes:

  • the IONA study only assessed the role of nicorandil as an 'add-on' therapy
  • the data from the IONA study would suggest that nicorandil may be a worthwhile add-on therapy (number needed to treat 42 for 1.6 years for the primary combined endpoint) for certain patients considered to be at high risk of a cardiovascular event (e.g. 66% of patients in IONA had a previous MI)
  • in the IONA study nicorandil was used with various combinations of antianginals including beta-blockers, calcium channel blockers and long-acting nitrates - therefore the IONA study does not provide information as to when to add in nicorandil

Reference:

  1. The IONA Study Group. Effect of nicorandil on coronary events in patients with stable angina: the Impact of Nicorandil in Angina (IONA) randomised trial. Lancet 2002, 359:1269-75.

Create an account to add page annotations

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.