This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Go to /pro/cpd-dashboard page

This page is worth 0.05 CPD credits. CPD dashboard

Go to /account/subscription-details page

This page is worth 0.05 CPD credits. Upgrade to Pro

Energy production (tricarboxylic acid cycle)

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

The tricarboxylic acid cycle can produce the equivalent of 12 molecules of ATP per molecule of acetyl-CoA oxidized. This is produced as follows:

  • isocitrate dehydrogenase produces 1 molecule of NADH
  • oxoglutarate dehydrogenase produces 1 molecule of NADH
  • succinyl-CoA synthetase produces 1 molecule of GTP
  • succinate dehydrogenase produces 1 molecule of FADH2
  • malate dehydrogenase produces 1 molecule of NADH

Via the electron transport chain, each molecule of NADH produces 3 molecules of ATP. The FADH2 coenzyme of succinate dehydrogenase can produce 2 molecules of ATP.

Overall, counting the 3 molecules of ATP for each reaction that pyruvate dehydrogenase catalyzes, the complete oxidation of 1 molecule of glucose via glycolysis and the tricarboxylic acid cycle can yield 38 molecules of ATP.


Create an account to add page annotations

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.