Cautions/contraindications
Cautions:
- diabetes
- gout
- may exacerbate systemic lupus erythematosus
- pregnancy and breast feeding
- ineffectual if renal impairment - serum creatinine > 150 micromol/litre; use a loop diuretic instead
- hepatic impairment
- hyperlipidaemia is not a contraindication because the long-term effect of low doses on lipids is trivial
Contra-indications
- refractory hyponatraemia, hypokalaemia, hypercalcaemia
- severe hepatic and renal impairment
- symptomatic hyperuricaemia
- Addison's disease
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