Cholinergic urticaria

Cholinergic urticaria

• this is a distinctive condition in which numerous intensely itchy, pin-head papules develop some 10 minutes after sweating (during physical exercise, taking a bath, raising the body temperature, and during emotional stress)
• typically it can be seen in young adults
• susceptible individuals show an exaggerated response to the introduction of ACh derivatives to the skin (1)
• severe attacks are followed by a refractory period of 1-2 days. Some times it may be associated with by angioedema and anaphylactic reactions (1)

Reference:

• 1. Fukunaga A et al. Responsiveness to autologous sweat and serum in cholinergic urticaria classifies its clinical subtypes. J Allergy Clin Immunol 2005;116:397-402