Trials with respect to treatment of hypercholesterolaemia
There have been very many studies looking at the effects of lowering serum cholesterol, of which here trials such as the MRFIT, POSCH, Scandinavian Simvastatin Survival study, CARE trial, VA-HIT, WOSCOPS and MRC/BHF Heart Protection study are briefly reviewed. These show that reduction of cholesterol is worthwhile in primary and secondary prevention of coronary heart disease (CHD).
Some trials involving lipid lowering treatments are linked below.
Related pages
- Air Force/Texas Coronary Atherosclerosis Prevention study
- Anglo-Scandinavian Cardiac Outcomes Trial ( ASCOT ) - Lipid Arm
- ARBITER 2
- ASPEN study
- ASTEROID trial
- AVERT trial
- Collaborative Atorvastatin Diabetes Study (CARDS or CARD study)
- Cholesterol Treatment Trialists' Collaborators meta-analysis 2005
- Cholesterol and recurrent events trial
- GREACE (GREek Atorvastatin Coronary-heart-disease Evaluation) study
- IDEAL study
- Intensive statin therapy in acute coronary syndromes and stable coronary heart disease: a meta-analysis (Afilalo J et al, 2007)
- Justification for the Use of Statins in Primary Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) study
- LIPID study
- MRC/BHF Heart Protection Study ( HPS )
- MIRACL study, atorvastatin
- MRFIT study
- Population based cohort study of statin use via analysis of QResearch database
- POSCH study
- Primary prevention with statin therapy meta-analysis (Thavendiranthan et al, 2006)
- Prospective Studies Collaboration meta-analysis - blood cholesterol and vascular mortality by age, sex and blood pressure
- Prospective Study of Pravastatin in the Elderly ( PROSPER )
- PROVE-IT and REVERSAL - the concept of the lower the better for cholesterol therapy in patients with coronary heart disease
- SAGE (Study Assessing Goals in the Elderly)
- Scandinavian Simvastatin Survival Study
- Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) trial
- SPARCL (Stroke Prevention by Aggressive Reduction in Cholesterol Levels) trial
- Treating to New Targets (TNT) study
- West of Scotland Coronary Prevention Study
- Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Study
- Helsinki Heart Study
- Bezafibrate Infarction Prevention Study
- FIELD study
- Cholesterol
- Statins for primary prevention of cardiovascular disease (Cochrane review 2013)
- IMPROVE-IT (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial) - ezetimibe plus statin in high risk patients with cardiovascular disease
- Canakinumab Antiinflammatory Thrombosis Outcome Study (CANTOS) trial
- Evolocumab and clinical outcomes in patients with cardiovascular disease (FOURIER study)
- Alirocumab and cardiovascular outcomes after acute coronary syndrome - Odyssey study
- Copenhagen General Population Study - LDL-C and all-cause mortality risk
- RACING - long-term efficacy and safety of moderate-intensity statin with ezetimibe combination therapy versus high-intensity statin monotherapy
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