a meta-analysis and meta-aggression of 35 randomized controlled trials was undertaken to investigate whether statin treatment had a protective effect on cancer risk
the authors however did not find evidence to support a protective effect of statins against cancer
however the authors noted that this conclusion was limited by the relatively short follow-up periods (4.5 years on average) of the studies analyzed
a prospective open cohort study has examined and quantified the unintended risks and benefits of statins in a large representative primary care population over a six year period
with respect to risk of oesophageal cancer and statin treatment (2)
risk of oesophageal cancer decreased in both men and women associated with statin treatment
based on the 20% threshold for cardiovascular risk, for women the NNT with any statin to prevent one case of cardiovascular disease over five years was 37 (95% confidence interval 27 to 64) and for oesophageal cancer was 1266 (850 to 3460) and for men the respective values were 33 (24 to 57) and 1082 (711 to 2807)
statin use in heart failure
Qing-Wen et al undertook a study that suggests that statin use is associated with a significantly lower risk of incident cancer and cancer-related mortality in HF, an association that appears to be duration dependent
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