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Production

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Histamine is produced by the action of histidine decarboxylase on histidine. It is stored in cells in granules in conjunction with acidic protein and a glycosaminoglycan. It is found in most tissues but in highest concentration in:

  • gastrointestinal tract, particularly the stomach
  • lungs
  • skin

Histamine is found in the following cells:

  • mast cells in connective tissues
  • basophils of blood; at lower concentration than in mast cells
  • platelets

The production of histamine in basophils is relatively slow in comparison to mast cells, particularly those in the stomach.

Reference

  1. Lieberman P. The basics of histamine biology. Ann Allergy Asthma Immunol. 2011 Feb;106(2 Suppl):S2-5

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