Round Up Email January 2024 – Primary Care Notebook

With respect to the surgical treatment of obesity, which statement is false?

laparoscopic sleeve gastrectomy consists of a 70% vertical gastric resection, which creates a long and narrow tubular gastric reservoir with no intestinal bypass component
observational studies show that metabolic/bariatric surgery is associated with a lower incidence of cardiovascular events, cancer, and death
laparoscopic adjustable gastric banding combines a subtotal (2/3rds) distal gastrectomy and a very long Roux-en-Y anastomosis with a short common intestinal channel for nutrient absorption

Use of spironolactone in acne vulgaris: Spironolactone in acne vulgaris

With respect to the use of spironolactone in acne vulgaris, which statement is false?

diuretic effect of spironolactone may benefit women who experience a premenstrual acne flare associated with fluid retention
spironolactone characteristically may exacerbate hirsutism if present with acne vulgaris
the use of spironolactone in acne vulgaris is likely to take 3-6 months to work

GLP-1 Receptor Agonists and thyroid cancer risk: GLP1 receptor agonists and thyroid cancer risk

With respect to GLP1 receptor agonists and thyroid cancer risk, which statement is true?

A systematic review and meta-analysis found GLP-1 receptor agonist treatment was associated with an increased risk of overall thyroid cancer by about 10%
A systematic review and meta-analysis found GLP-1 receptor agonist treatment was associated with an increased risk of overall thyroid cancer by about 50%
A systematic review and meta-analysis found GLP-1 receptor agonist treatment was associated with an increased risk of overall thyroid cancer by about 70%

Shingles vaccine update : Shingles vaccine

With respect to the Shingles vaccine, which statement is false?

age-related increase in disease correlates closely with the decline in VZV (varicella zoster virus) -specific T cell mediated immunity (VZV-CMI) that accompanies aging
Varicella zoster virus (VZV) antibody declines markedly with aging
study evidence found two doses of recombinant zoster vaccine were highly effective, with effectiveness generally maintained over 4 years

Use of benzodiazepines in pregnancy : Benzodiazepines in pregnancy

With respect to the use of benzodiazepines in pregnancy, which statement is false?

during late pregnancy, or during labour, use of high doses of benzodiazepines may result in neonatal hypotonia and/or hypothermia
physical dependence may occur in infants born to mothers who take benzodiazepines chronically
benzodiazepines are not excreted in the breast milk

Aripiprazole and pathological gambling : Aripiprazole and pathological gambling

With respect to aripiprazole and pathological gambling, which statement is false?

Aripiprazole is a full D2 receptor agonist
dopamine replacement therapy acts via dopamine receptors in the nigrostriatal pathway and in the reward pathway, which plays a role in addiction
study evidence showed that patients in the ariprazole group seemed to be more severe problem gamblers than patients in the DRT (dopamine replacement therapy) group