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Round Up Email August 2022

This month's Round Up includes updates with respect to the evidence base in hormone replacement therapy (HRT) as well as new prescribing guidance for Clostridium Associated Diarrhoea (CAD) and a summary of the "Target in Range" parameter used in Continuous Glucose Monitoring (CGM) for diabetes.

  • Question 1

    The RACING study – new evidence for the benefits of ezetimibe in reducing cardiovascular risk – The evidence base previously for ezetimibe has been fairly limited in terms of reducing cardiovascular risk endpoints; with IMPROVE-IT being the highlight. The RACING study showed that that moderate-intensity statin with ezetimibe combination therapy was non-inferior to high-intensity statin monotherapy in patients with ASCVD (atherosclerotic cardiovascular disease) in reducing cardiovascular risk in the long term – providing GPs more confidence in the efficacy of using a statin plus ezetimibe combination in patients at high cardiovascular risk.: RACING - long-term efficacy and safety of moderate-intensity statin with ezetimibe combination therapy versus high-intensity statin monotherapy

    1) With respect to the evidence base with respect to ezetimibe, which statement is false?

  • Question 2

    Mindfulness-based cognitive therapy (MBCT) – what is this form of psychological therapy? Is MBCT effective in depression? What about generalised anxiety disorder (GAD)?: Mindfulness-based cognitive therapy (MBCT)

    2) With respect to mindfulness-based cognitive therapy (MBCT), which statement is false?

  • Question 3

    Smoking cessation and E cigarettes - How does the effectiveness of nicotine E cigarettes compare to nicotine replacement therapy in achieving smoking cessation? Are E cigarettes with nicotine more effective in achieving smoking cessation goals than non-nicotine E cigarettes?: Smoking cessation and E-cigarettes

    3) With respect to E cigarettes and smoking cessation, which statement is false?

  • Question 4

    Clostridium-associated diarrhoea(CAD) – is metronidazole the first-line antibiotic indicated for CAD? Is Fidaxomicin an option for first-line antibiotic therapy for CAD?: Pseudomembranous colitis

    4) With respect to Clostridium-associated diarrhoea (CAD), which statement is false

  • Question 5

    "Target Time in Range" – what is this indicator of glycaemic control for diabetics? How does "time in range" approximate to an estimate of HbA1c?: Target time in range (TIR) in diabetes

    5) With respect to "Target time in Range", which statement is false?

  • Question 6

    Hormone Replacement Therapy (HRT) in patients with a history of breast cancer – this section on GPnotebook has been updated.: Hormone replacement therapy (HRT) in patients with breast cancer

    6) With respect to the use of HRT in patients with a history of breast cancer, which statement is false?