The penicillins interfere with cell wall synthesis and are bactericidal. They cause inhibition of bacterial cell wall synthesis through the inhibition of a membrane-bound transpeptidase.
The weakened cell wall results in lysis and cell wall death.
Bacterial resistance occurs as a result of bacterial production of beta-lactimase (penicillinase) that splits the beta-lactam ring of the penicillin nucleus.
The principle organisms that produce penicillinase are:
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