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Clinical features

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

  • subcutaneous chancre develops at site of the bite of an infected tsetse fly

  • irregular fevers and weakness

  • lymphadenopathy:
    • especially posterior cervical nodes in T. gambiense infection - Winterbottom's sign

  • other features
    • headache
    • arthralgia
    • weight loss
    • peripheral and pulmonary oedema
    • pericardial effusions
    • ascites
    • nephritis
    • amenorrhoea/impotence

  • late features:

  • CNS disturbance:
    • ataxia
    • dyskinesias
    • dementia
    • hypersomonelence
    • coma

  • psychiatric disturbance:
    • apathy
    • depression
    • reversal of the sleep-wake cycle

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